Perampanel in the additional therapy of focal and primary generalized tonic-clonic seizures in children 4–12 years old: clinical data, experience of use and practical recommendations
https://doi.org/10.17749/2077-8333/epi.par.con.2021.087
Abstract
On March 18, 2021, an online council of experts in the field of epilepsy treatment was held, dedicated to the use of perampanel in the additional therapy of focal seizures (FS) and primary generalized tonic-clonic seizures (PGTCS) in children 4–12 years old. During the event, the features of the use of perampanel in this group of patients were discussed, considering the specifics of everyday clinical practice, current possibilities of PGTCS and FS therapy in children, its goals, as well as unsolved problems in the treatment of pediatric patients with PGTCS and FS. Particular attention was paid to the role of perampanel in the treatment of PGTCS and FS in children and its effectiveness in specific types of focal seizures.
Keywords
epilepsy,
children,
therapy features,
primary generalized tonic-clonic seizures,
focal seizures,
perampanel,
clinical practice,
quality of life
Supporting agencies: This article was published with the financial support of Eisai Co., Ltd. The authors are fully responsible for the content of the article and editorial decisions.
About the Authors
K. Yu. Mukhin
St. Luke Institute of Pediatric Neurology and Epilepsy
Russian Federation
Russian Federation
Konstantin Yu. Mukhin – Dr. Med. Sc., Professor, Head of Clinic
9 Academician Anokhin Str., Moscow 119571
E. D. Belousova
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Elena D. Belousova – Dr. Med. Sc., Professor, Head of the Department of Psychoneurology and Epileptology, Research Clinical Institute of Pediatrics
1 Ostrovityanov Str., Moscow 117997
S. G. Burd
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Sergey G. Burd – Dr. Med. Sc., Professor, Chair of Neurology, Neurosurgery and Medical Genetics
1 Ostrovityanov Str., Moscow 117997
M. V. Barkhatov
Federal Siberian Scientific and Clinical Center, Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Mikhail V. Barkhatov – MD, PhD, Director, Center for Epileptology and Pediatric Neurology
26 Kolomenskaya Str., Krasnoyarsk 660037
N. A. Ermolenko
Voronezh Regional Clinical Hospital No. 1
Russian Federation
Russian Federation
Natalia A. Ermolenko – Dr. Med. Sc., Head of the Neurological Departmen
151 Moskovskiy Prospect, Voronezh 394068
S. K. Zyryanov
Peoples’ Friendship University of Russia; City Clinical Hospital No. 24
Russian Federation
Russian Federation
Sergey K. Zyryanov – Dr. Med. Sc., Professor, Head of Department of General and Clinical Pharmacology, Peoples’ Friendship University of Russia; Deputy Chief Physician for Therapy, City Clinical Hospital No. 24
8 corp. 2 Miklukho-Maklay Str., Moscow 117198
10 Pistsovaya Str., Moscow 127015
E. I. Karpovich
Nizhny Novgorod Semashko Regional Clinical Hospital
Russian Federation
Russian Federation
Ekaterina I. Karpovich – Dr. Med. Sc., Head of Neurophysiology Department
190 Rodionov Str., Nizhny Novgorod 603126
E. A. Morozova
Kazan State Medical Academy – branch of Russian Medical Academy of Continuing Professional Education
Russian Federation
Russian Federation
Elena A. Morozova – Dr. Med. Sc., Professor, Head of Department of Pediatric Neurology
11 Mushtari Str., Kazan 420012
G. V. Odintsova
Almazov National Medical Research Center
Russian Federation
Russian Federation
Galina V. Odintsova – MD, PhD, Head of Research Laboratory of Epileptology
2 Akkuratov Str., Saint Petersburg 197341
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Review
For citations:
Mukhin K.Yu., Belousova E.D., Burd S.G., Barkhatov M.V., Ermolenko N.A., Zyryanov S.K., Karpovich E.I., Morozova E.A., Odintsova G.V. Perampanel in the additional therapy of focal and primary generalized tonic-clonic seizures in children 4–12 years old: clinical data, experience of use and practical recommendations. Epilepsy and paroxysmal conditions. 2021;13(2):180-187. (In Russ.) https://doi.org/10.17749/2077-8333/epi.par.con.2021.087
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