LEVETINOL IN COMPLEX TREATMENT OF FOCAL EPILEPSY (EXPERIENCE OF EPILEPTOLOGIST IN OUTPATIENT NETWORK, MOSCOW)
Abstract
Abstract: prescription of Levetinol in regimen of integrated adjunctive therapy in 30 patients with symptomatic and cryptogenic focal forms of epilepsy with poorly controlled seizures, receiving the reference probe of antiepileptic drugs, was accompanied by the attainment of a higher therapeutic effect. Remission with an average effective dose of the drug 1437.5 mg/day was observed in 6, reduction of attacks by 75% – in 8 patients. Levetinol significantly affect the indicators of anxiety and depression in the reduction of symptoms of affective disorders.
About the Authors
G. G. Avakyan
Polyclinic №220 Moscow Health Department
Russian Federation
Russian Federation
M. A. Bogomazova
Polyclinic №107 Moscow Health Department
Russian Federation
Russian Federation
I. I. Zhuravleva
Polyclinic №180 Moscow Health Department
Russian Federation
Russian Federation
A. M. Ismailov
Polyclinic №218 Moscow Health Department
Russian Federation
Russian Federation
E. G. Komelkova
Moscow State University of Medicine and Dentistry
Russian Federation
Russian Federation
L. N. Lesinker
Polyclinic №62 Moscow Health Department
Russian Federation
Russian Federation
Yu. I. Logvinov
City Clinical Hospital named after S.P. Botkin Moscow Health Department
Russian Federation
Russian Federation
O. V. Otcheskaya
Polyclinic №19 Moscow Health Department
Russian Federation
Russian Federation
S. V. Petrov
Russian Federation
Yu. V. Rubleva
Polyclinic №220 Moscow Health Department
Russian Federation
Russian Federation
Yu. V. Solomatin
Polyclinic №1 Moscow Health Department
Russian Federation
Russian Federation
A. M. Teplysheva
Polyclinic №62 Moscow Health Department
Russian Federation
Russian Federation
T. N. Udovychenko
Russian Federation
E. A. Chromich
Polyclinic №19 Moscow Health Department
Russian Federation
Russian Federation
R. K. Shichkerimov
Polyclinic №166 Moscow Health Department
Russian Federation
Russian Federation
M. M. Shomachowa
Russian Federation
References
1. Avakyan G.N. Epilepsiya i paroksizmal’nye sostoyaniya. 2014; 3 (S): 1-3.
2. Badalyan O.L. Epilepsiya i paroksizmal’nye sostoyaniya. 2011; 3: 53.
3. Gekht A.B., Shprakh V.V., Kabakov R.A., Golovanova I.V. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2004; 104 (6): 23-27.
4. Zenkov L.R. Nevrologicheskii zhurnal. 2007; 12 (3): 8-13.
5. Telnova E.A. Farmakoekonomika. Sovremennaya farmakoekonomika i farmakoepidemiologiya. 2010; 1: 12-18.
6. Telnova E.A., Rumyantsev A.S., Romanov F.A. Farmakoekonomika. Sovremennaya farmakoekonomika i farmakoepidemiologiya. 2010; 1: 19-25.
7. Shnaider N.A., Pilyugina M.S., Dmitrenko D.V., Shmatova E.N., Erykalova S.A. Epilepsiya i paroksizmal’nye sostoyaniya. 2010; 4: 32-36.
8. Cram L., Dulac O., Frey H. Commission on antiepileptic drags of the International League Against Epilepsy Guidelines for antiepileptic drug trials in children. 1994.
9. Glauser T., Ben-Menachem E., Bourgeois B. et al. ILAE Subcommission on AED Guidelines. Updated ILAE evidence review of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes. Epilepsia. 2013 Mar; 54 (3): 551-63.
10. Johannessen S.I., Ben-Menachem E. Management of Focal-Onset Seizures. An Update on Drug Treatment. Drugs. 2006; 66 (13): 1701-1725.
11. Kwan P., Brodie M.J. Refractory epilepsy: mechanisms and solutions. Expert Rev Neurother. 2006; 6 (3): 397-406.
Review
For citations:
Avakyan G.G., Bogomazova M.A., Zhuravleva I.I., Ismailov A.M., Komelkova E.G., Lesinker L.N., Logvinov Yu.I., Otcheskaya O.V., Petrov S.V., Rubleva Yu.V., Solomatin Yu.V., Teplysheva A.M., Udovychenko T.N., Chromich E.A., Shichkerimov R.K., Shomachowa M.M. LEVETINOL IN COMPLEX TREATMENT OF FOCAL EPILEPSY (EXPERIENCE OF EPILEPTOLOGIST IN OUTPATIENT NETWORK, MOSCOW). Epilepsy and paroxysmal conditions. 2014;6(4):23-28. (In Russ.)
Views: 637
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Email this article 
